Penn Compact 2022 affirms the commitment we share with our founder:
to put knowledge into action for the greatest good.

Amy Gutmann


The culture and practice of innovation has been central to Penn’s mission since America’s first inventor-entrepreneur, Benjamin Franklin, founded the University more than two centuries ago. The Penn Compact 2022 renews this forward-thinking tradition to meet the needs of its 21st century faculty and students as they create new knowledge and develop new technology for the advancement of society. Today, thanks to long term investments and consistent support from executive leadership, Penn is proud to be one of the nation’s top research universities. Recently, the University was ranked by Reuters among the Top 5 most innovative universities in the world.

Dr. Gutmann has helped Penn launch a brand-new campus devoted to innovation—the 23-acre Pennovation Works. At the heart of the site is the Pennovation Center, a business incubator and laboratory where researchers, entrepreneurs, and industry partners—including The Hershey Company, Johnson & Johnson Innovation (JLABS), and Qualcomm Research Philadelphia—collaborate to solve pressing real-world problems. The Penn Center for Innovation has also been established to fast-track Penn technologies to meet social and environmental needs.


Innovation is much more than traditional patenting and technology transfer. It is about creating an innovation ecosystem that fosters a fluid exchange of ideas and expertise across a broad spectrum of new and established knowledge.

Amy Gutmann

Other prominent innovation initiatives at Penn include the President’s Innovation Prize, which incentivizes students to devise and develop commercial projects with social impact. Dr. Gutmann established the annual prize to provide student teams with all the support necessary to put their Penn-generated knowledge, skills, and experiences into practice immediately upon graduating.

The Penn Integrates Knowledge (PIK) professorships recruit faculty renowned for their groundbreaking, discipline-defying work. By providing each PIK professor with appointments in two or more Penn schools, this initiative leverages the extensive network of meaningful exchanges that take place among the University’s 12 schools. Most recently, Dr. Gutmann announced world-renowned social psychologist Dolores Albarracín, who has joint appointments in the Annenberg School for Communication and the School of Nursing, as Penn’s 28th PIK professor.

From the time ENIAC, the world’s first computer, was developed and introduced on campus in 1946, Penn Engineering has continued a tradition of leadership and cutting-edge research in fields including autonomous robots, computer vision, cybersecurity, embedded systems and IoT, mechanobiology and the physics of cancer, metamaterials, network neuroscience, photonic computing, privacy algorithms, self-assembling nanomaterials, and tribology. These initiatives have only been boosted in recent years with new facilities including the Singh Center for Nanotechnology.

Across campus, new interdisciplinary hubs for innovation have been strategically created, including the Smilow Center for Translational Research, Wharton Academic Research Building, the Center for Health Care Innovation, and the soon-to-open New Patient Pavilion and Vagelos Energy Building. In addition, under Dr. Gutmann’s guidance, innovation programs that touch on a variety of disciplines, spanning the likes of the Vagelos Integrated Program in Energy Research and the Mack Institute for Innovation Management to the Penn Vet Working Dog Center, have been able to flourish.

In the health sciences, the Perelman School of Medicine offers a flexible MD curriculum allowing students to participate in dual-degree programs, including the MD/PhD and MD/JD along with several master’s programs. In 2021, 66% of the 156 Penn Medicine graduates pursued more than just the MD Degree, including 64 students who earned a total of 76 certificates in addition to the dual degree students. Among these programs is the NIH-funded MD/PhD Medical Scientist Training Program, which was one of the first of its kind and is the largest in the country, with 217 students. An unusually high percentage of these students—nearly 20 percent—earn their PhDs outside of the biological sciences, reflecting Penn’s strong emphasis on interdisciplinary collaboration and the MD/PhD program’s embrace of the One University concept.

Penn Medicine’s foundational connectivity among research, clinical trials, and patient care established Penn as a pioneer of translational medicine, a title that rings true today. Penn Medicine’s groundbreaking research has resulted in 13 FDA approvals for new treatments including the first personalized cellular therapy for cancer, and Penn researchers and clinicians have propelled advances in testing, treatment, and prevention of COVID-19 that has helped to give hope to billions of people worldwide during the coronavirus pandemic. For instance, Perelman School of Medicine researchers developed the mRNA vaccine technology that is a critical component of Pfizer/BioNTech’s and Moderna’s COVID-19 vaccines, which are being deployed globally in the fight against the virus.

Signature Initiatives

Created by President Amy Gutmann to strengthen Penn’s commitment to innovation, the President’s Innovation Prize awards a graduating Penn senior, or a team of graduating seniors, $100,000 (plus a $50,000 living stipend per team member) to envision and implement an innovative, commercial venture that makes a positive difference in the world.

Visit site

The Pennovation Works is anchored by the Pennovation Center, a business incubator and laboratory that aligns and integrates researchers, innovators, and entrepreneurs for the commercialization of research discoveries. Intended to marry entrepreneurs with an expert workforce and scientifically advanced facilities, key features of the Pennovation Center are the common creative spaces, including coworking areas, a cafe, and a venue for events and programs.

Visit site

The endowed Penn Integrates Knowledge (PIK) Professorship is an initiative to recruit renowned scholars whose achievements demonstrate a rare ability to work at the intersection of multiple fields. With appointments in two or more Penn schools, PIK Professors can draw from their expertise in diverse disciplines to find creative solutions for complex, real-world problems.

Visit site

PCI helps to translate Penn discoveries and ideas into new products and businesses for the benefit of society. It does this by facilitating technology development connections between Penn and the private sector. Whether the end result is a technology license, an R&D alliance, and/or the formation of a new venture, PCI serves as a dedicated one-stop shop for commercial partnering with Penn.

Visit site

Penn Compact Innovation in the News

These obese mice lost weight by ‘sweating’ their fat, Penn team finds
Philadelphia Inquirer | 2021-07-30 Taku Kambayashi and med student Ruth Chao of the Perelman School of Medicine found that they could stimulate fat loss in obese mice by treating the animals with a type of cytokine.
Uterus transplant enables woman to have a baby after doctors said she couldn’t
Today | 2021-07-16 Kathleen O’Neill of the Perelman School of Medicine spoke about a Penn Medicine uterus transplant trial. “These women have ovaries, they have eggs, they just don’t have the uterus to gestate the pregnancy,” said O’Neill. “So once we are able to give them that uterus, the vast majority get pregnant and have babies.”
Penn finds a surprising benefit to wisdom tooth surgery: better taste
Philadelphia Inquirer | 2021-07-03 Research by Richard Doty of the Perelman School of Medicine and Dane Kim, a student in the School of Dental Medicine, found that people who have had wisdom teeth removed had a slightly stronger sense of taste over time. Earlier studies have focused on the temporary loss of taste associated with the procedure.
The largest comet ever discovered in modern times is zooming toward the sun
USA Today | 2021-06-29 Gary Bernstein of the School of Arts & Sciences spoke about the giant comet he and Ph.D. candidate Pedro Bernardinelli discovered. "We have the privilege of having discovered perhaps the largest comet ever seen—or at least larger than any well-studied one—and caught it early enough for people to watch it evolve as it approaches and warms up," Bernstein said.